How to cite item

A new tool in the cancer immunotherapy toolbox?

   
@article{AOL4411,
	author = {Xiaosheng Wu and Thomas E. Witzig},
	title = {A new tool in the cancer immunotherapy toolbox?},
	journal = {Annals of Lymphoma},
	volume = {2},
	number = {3},
	year = {2018},
	keywords = {},
	abstract = {Programmed cell death-1 (PD-1), a member of the CD28 superfamily, is primarily expressed on the surface of T cells. The normal function of PD-1 is to dampen the immune activity and promote self-tolerance of activated CD8+ cytotoxic T cells by suppressing T cell inflammatory reactions. Binding of PD-1 with its ligand PD-L1 (or B7-H1) or PD-L2 (or B7-DC) excessively leads to the exhaustion of CD8+ cytotoxic T cells (1). In most of patients with advanced cancers, CD8+ cytotoxic T cells are exhausted owing to the engagement of PD-1 by the aberrantly expressed PD-L1 on tumor cells and/or nurse cells in the tumor microenvironment.},
	issn = {2616-2695},	url = {https://aol.amegroups.org/article/view/4411}
}