Primary central nervous system lymphoma

Primary central nervous system lymphoma

Primary central nervous system lymphoma is a challenging neoplasm with peculiar biological and clinical features. Its increasing incidence, peculiar clinical behavior and aggressiveness as well as the distinctive biological and immunological features of the central nervous system represent several challenges in diagnosis, treatment and basic knowledge on this tumor. Technological achievements in neuroimaging resulted in earlier and more accurate diagnostic suspicion, and an increased number of patients with histopathologically confirmed diagnosis. Higher availability of biological and tissue samples and the use of recently developed, highly performing molecular techniques produced substantial knowledge in the molecular and genetic properties of this neoplasm. In this scenario, international cooperation played a central role, with the establishment of working groups that designed and completed large randomized trials, focused on relevant open questions. In the last decade, international cooperation established consolidated therapeutic guidelines and advanced our learning in some peculiar settings, like vitreoretinal lymphoma and neurolymphomatosis. Basic research critically contributed to these achievements, mostly on activated tumor pathways that could represent suitable targets for novel therapies. The efforts of several multidisciplinary experts led to relevant improvement in outcome and quality of life of patients affected by this dismal disease. Many of these internationally recognized experts contributed to summarize the current knowledge, discuss evidence, provide recommendations, and foresee possible scenarios in this special series of Annals of Lymphoma. Editors wish to thank authors but also several other experts that acted as peer reviewers of the article reviews, contributing anonymously and enthusiastically to improve the quality of this series.


Funding: None.


Provenance and Peer Review: This article was commissioned by the editorial office, Annals of Lymphoma for the series “Central Nervous System Lymphomas”. The article did not undergo external peer review.

Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form ( The series “Central Nervous System Lymphomas” was commissioned by the editorial office without any funding or sponsorship. AJMF served as the unpaid Guest Editor of the series and serves as an unpaid editorial board member of Annals of Lymphoma from March 2020 to February 2022. MP served as the unpaid Guest Editor of the series. The authors have no other conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See:

Andrés J. M. Ferreri
Maurilio Ponzoni

Andrés J. M. Ferreri1


Maurilio Ponzoni1,2,3


1Lymphoma Unit, Department of Onco-Hematology, IRCCS San Raffaele Scientific Institute, Milano, Italy;
2Pathology Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy;
3Ateneo Vita e Salute San Raffaele, Milano, Italy

Received: 08 September 2021; Accepted: 08 October 2021; Published: 30 December 2021.

doi: 10.21037/aol-21-31

doi: 10.21037/aol-21-31
Cite this article as: Ferreri AJM, Ponzoni M. Primary central nervous system lymphoma. Ann Lymphoma 2021;5:34.

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